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pentobarbital will reduce the extent or result of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Pitolisant exposure is decreased by 50% if coadministered with powerful CYP3A4 inducers.pentobarbital will minimize the extent or influence of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4